LEAN J’s open label device, Short treatment period and the small numbers of patients are boundaries that need further validation from RCTs such as LEAN, But could be predictive of success for the important scale study. There have been a substudy of 14 LEAN patients, In which liraglutide profoundly decreased weight, Fasting carbs and sugar and carbohydrates, Liver mineral deposits, Plus lipogenesis(Fat formation) In comparison with placebo. Liraglutide also tremendously improved serum markers of adipose inflammation compared with placebo.

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